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tren 100 side effects

Tren 100 side effects – bacteriostatic antibiotic with broad-spectrum macrolide-azalide. It has a wide spectrum of antimicrobial action. The mechanism of action of tren 100 side effects is associated with the suppression of the microbial cell protein synthesis. By binding to the 50S – subunit of the ribosome inhibits translation peptidtranslokazu on stage and inhibits protein synthesis, slowing the growth and reproduction of bacteria. In high concentrations it has a bactericidal effect.

It has activity against a number of Gram-positive, Gram-negative, anaerobic, and other intracellular microorganisms.

Microorganisms can be initially resistant to antibiotics or may acquire resistance to it.

Most sensitive microorganisms

1. Gram-positive aerobes

Staphylococcusaureus Methicillin-sensitive;

Streptococcuspneumoniae Penicillin-sensitive;

Pyogenes Streptococcus .

2. Gramotritsatelnyeaeroby

Influenzae Haemophilus ;

Parainfluenzae of Haemophilus ;

Pneumophila of Legionella ;

Catarrhalis of Moraxella ;

Multocida of Pasteurella ;

Gonorrhoeae of Neisseria .

3. Anaerobes

Perfringens Clostridium ;

Spp Fusobacterium. ;

Spp Prevotella. ;

Porphyriomonas spp.

4. Other microorganisms

Trachomatis Chlamydia ;

Pneumoniae Chlamydia ;

Psittaci of Chlamydia ;

Pneumoniae Mycoplasma ;

Hominis of Mycoplasma ;

Burgdorferi of Borrelia .

Organisms capable of developing resistance to tren 100 side effects

gram-positive aerobes

Streptococcuspneumoniae Penicillin-sensitive.

Initially resistant microorganisms

gram-positive aerobes

Enterococcusfaecalis ;

Staphylococci (methicillin-resistant staphylococci exhibit a very high degree of resistance to macrolides);

Gram-positive bacteria resistant to erythromycin.

Anaerobes

Bacteroidesfragilis .

Pharmacokinetics:

tren 100 side effects is rapidly absorbed from the gastrointestinal tract due to its stability in an acidic medium and lipophilicity. It is rapidly distributed throughout trenbolone effects the body in tissues with high concentrations of antibiotic achieved. After oral administration of 500 mg of tren 100 side effects in the maximum concentration achieved in the plasma and 2.5-2.9 hours is 0.4 mg / l. Bioavailability is 37.5%.

tren 100 side effects well into the respiratory tract, genitourinary organs and tissues (in particular in the prostate gland), the skin and soft tissue. The high concentration in tissues (10-50 times higher than in blood plasma) and a long half-life of tren 100 side effects due to low binding to plasma proteins, and its ability to penetrate into eukaryotic cells and concentrated in a low pH environment, environmental lysosomes. This, in turn, defines a large apparent volume of distribution (31.1 l / kg) and high plasma clearance. The ability of tren 100 side effects to accumulate mainly in lysosomes is particularly important to eliminate intracellular pathogens. It proved that phagocytes deliver tren 100 side effects localization of infection sites where it is released in the process of phagocytosis. The concentration of tren 100 side effects in the foci of infection was significantly higher than in healthy tissue (on average 24-34%) and correlated with the degree of inflammatory edema. tren 100 side effects remains in bactericidal concentrations within 5-7 days after the last dose, which allowed the development of short (3 day and 5 day) treatments.

The liver demethylated formed metabolites are inactive.

Excretion of tren 100 side effects from plasma passes in 2 stages: half-life of 14-20 hours in the range of 8 to 24 hours after dosing, and 41 h – in the range from 24 to 72 hours, which allows for preparation 1 time / day.

Withdrawal of the drug mainly in the bile unchanged, a small portion excreted by the kidneys.

Indications for use:

Infectious-inflammatory diseases caused by susceptible to malaria infections:

· Infections of the upper respiratory tract and upper respiratory tract (pharyngitis / tonsillitis, sinusitis, otitis media);

· Infections of the lower respiratory tract: acute bronchitis, exacerbation of chronic bronchitis, including caused by atypical pathogens;

· Infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatitis);

· The initial stage of Lyme disease (borreliosis) – erythema migrans ( Erythemamigrans );

· Infections of the urinary tract caused by Chlamydiatrachomatis (urethritis, cervicitis).

Contraindications:

· Hypersensitivity to macrolide antibiotics;

· Serious liver and kidney function;

· Children under 12 years of age with a body weight less than 45 kg (for a given dosage form);

· Breast-feeding;

· Simultaneous treatment with ergotamine and dihydroergotamine.

Carefully:

– Moderate impaired liver and kidney function;

– Arrhythmia or predisposition to arrhythmias and prolongation of QT interval;

– With a joint appointment terfenadine, warfarin, digoxin.

Pregnancy and lactation: Use of the drug during pregnancy is possible only when the intended benefits to the mother outweighs the potential risk to the fetus.

If necessary, the appointment during lactation should stop breastfeeding (excreted in breast milk).

Dosage and administration:

Inside, 1 times a day for at least 1 hour before or 2 hours after eating.

Adults (including the elderly) and children over 12 years weighing more than 45 kg.

With infections of the upper and lower respiratory tract infections, upper respiratory tract, skin and soft tissue

500 mg (2 capsules) 1 time per day for 3 days (a course dose – 1.5 g).

When the skin and soft tissue infections – 1 g / day for the first day of the 1 reception, followed by 0.5 g / day every day from 2 to 5 day (course dose – 3 g).

If erythema migrans

1 times a day for 5 days: Day 1 – 1.0 g (4 capsules), and then from the 2nd to 5th day – 500 mg (2 capsules) (course dose 3.0 g).

If urinary tract infections caused by Chlamydiatrachomatis (urethritis, cervicitis)

Uncomplicated urethritis / cervicitis – 1 g (4 capsules) once.

Appointment of patients with impaired renal function

For patients with moderate renal impairment (creatinine clearance> 40 ml / min) dose adjustment is not necessary.

Side effect:

Allergic reactions : itching, skin rash, angioedema, urticaria, anaphylactic reaction, including edema (in rare cases with fatal outcome), erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrosis.

From the circulatory and lymphatic systems : thrombocytopenia, neutropenia.

On the part of the central nervous system : dizziness / vertigo, headache, seizures, drowsiness, paresthesia, fatigue, insomnia, hyperactivity, aggressiveness, anxiety, nervousness.

From the senses : tinnitus, reversible hearing impairment including deafness (when taking high doses for a long time), impaired perception of taste and smell.

Since the cardiovascular system : rarely – palpitations, arrhythmia, ventricular tachycardia, increase the interval QT, bidirectional ventricular tachycardia.

From the digestive system : nausea, vomiting, diarrhea, abdominal pain / cramps, diarrhea, flatulence, indigestion, anorexia, constipation, change the language of color, pseudomembranous colitis, cholestatic jaundice, hepatitis, changes in laboratory parameters of liver function, liver dysfunction, necrosis liver (possibly fatal).

From the musculoskeletal system : arthralgia.

With the genitourinary system : nephritis, acute renal failure.

Other : vaginitis, candidiasis, photosensitivity.

Overdose:

Symptoms: nausea, temporary hearing loss, vomiting, diarrhea.

Treatment: gastric lavage, symptomatic therapy.

Interaction with other drugs:

Antacids do not affect the bioavailability of tren 100 side effects, but reduce the maximum blood concentration of 30%, so the drug should be taken at least one hour before or two hours after administration of these drugs and food.

tren 100 side effects concentration does not affect carbamazepine, didanosine, rifabutin and methylprednisolone in blood when used together.

For parenteral administration, tren 100 side effects does not affect the concentration of cimetidine, efavirenz, fluconazole, indinavir, midazolam, triazolam, in the blood of trimethoprim / sulfamethoxazole for sharing, but you should not exclude the possibility of such interactions in the appointment of tren 100 side effects for oral administration.

tren 100 side effects has no effect on the pharmacokinetics of theophylline, but when coadministered with other macrolides theophylline concentration in blood plasma can rise.

If necessary, the joint use with cyclosporin, it is recommended to control the content of cyclosporine in the blood. Despite the fact that the data on the influence of tren 100 side effects on a change in the blood concentration of cyclosporine no other members of the macrolide class capable of changing its level in the blood plasma.

When co-administered tren 100 side effects digoxin and digoxin is necessary to control the blood, as many macrolides digoxin enhance absorption in the gut, thereby increasing its concentration in blood plasma.

The joint appointment of warfarin and tren 100 side effects is recommended careful monitoring of the prothrombin time.

It has been found that co-administration of terfenadine and macrolide antibiotics class causes arrhythmia and QT interval elongation. Based on the fact, we can not exclude the above-mentioned complications by sharing a terfenadine and tren 100 side effects.

Since there is the possibility of inhibiting the enzyme CYP3A4 tren 100 side effects in parenteral form with a joint appointment with cyclosporine, terfenadine, ergot alkaloids, cisapride, pimozide, quinidine, astemizole and other drugs, the metabolism of which is mediated by the enzyme, one should consider the possibility of such an interaction in the appointment of tren 100 side effects for the reception inside.

When co-administered tren 100 side effects and zidovudine, tren 100 side effects does not affect the pharmacokinetic parameters of AZT in the blood plasma or its renal excretion and its glucuronide metabolite. However, increasing the concentration of the active metabolite – phosphorylated AZT mononuclear cells in peripheral blood vessels. The clinical significance of this fact is not clear.

At simultaneous reception of macrolides with ergotamine and dihydroergotamine possible manifestation of their toxic effect.

Special instructions:

Do not take with food.

In case of skipping the dose, the missed dose should be taken as soon as possible, and the next – with an interval of 24 hours.

Please observe a break of 2 hours, while the use of antacids.

After discontinuation of treatment hypersensitivity reactions in some patients may persist, which requires specific therapy under medical supervision.

Effects on ability to drive vehicles and mechanisms

tren 100 side effects has no effect on the ability to drive vehicles and mechanisms.

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