trenbolone

Broad-spectrum antibiotic, azalide, trenbolone bacteriostatic. By binding to the 50S – subunit of ribosomes, inhibits protein synthesis, inhibits the growth and reproduction of bacteria. In high concentrations it has a bactericidal effect. It works on the extra- and intracellular trenbolone pathogens.
It is active against Gram-positive microorganisms: Streptococcus spp. (groups C, F and G, except resistant to erythromycin), Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus viridans, Staphylococcus epidermidis, Staphylococcus aureus;
Gram-negative bacteria: Haemophilus influenzae, Moraxella catarrhalis, Bordetella pertussis, Bordetella parapertussis, Legionella pneumophila, Haemophilus ducreyi, Helicobacter pylori, Campylobacter jejuni , Neisseria gonorrhoeae trenbolone and Gardnerella vaginalis; Some anaerobic microorganisms: Bacteroides bivius, Clostridium perfringens, Peptostreptococcus spp .;
and intracellular pathogens: Chlamydia trachomatis, Chlamydia pneumoniae, Mycoplasma pneumoniae, Mycobacterium avium complex, Ureaplasma urealyticum, Treponema pallidum, Borrelia burgdorferi.
not active against Gram-positive bacteria resistant to erythromycin .

Pharmacokinetics of
trenbolone is rapidly absorbed from the gastrointestinal tract due to its stability in an acidic medium and lipophilicity. It is rapidly distributed throughout the body in tissues with high concentrations of antibiotic achieved. After oral administration of 500 mg of trenbolone in the maximum concentration achieved in the blood plasma of 2.5 – 2.9 hours, and 0.4 mg / l. Bioavailability is 37.5%.
trenbolone well into the respiratory tract, organs and tissues of the urogenital tract (including the prostate), the skin and soft tissue. The high concentration in tissues (10-50 times higher than in blood plasma) and a long half-life of trenbolone due to low binding to plasma proteins, and its ability to penetrate into eukaryotic cells and concentrated in a low pH environment, environmental lysosomes. This, in turn, defines a large apparent volume of distribution (31.1 l / kg) and high plasma clearance. The ability of trenbolone to accumulate mainly in lysosomes is particularly important to eliminate intracellular pathogens. It proved that phagocytes deliver trenbolone localization of infection sites where it is released in the process of phagocytosis. The concentration of trenbolone in the foci of infection was significantly higher than in healthy tissue (on average 24-34%) and correlated with the degree of inflammatory edema. trenbolone remains in bactericidal concentrations within 5-7 days after the last dose, which allowed the development of short (3 day and 5 day) treatments.
Demethylated in the liver, are not active metabolites formed.
Elimination of trenbolone from plasma passes to stage 2 : half-life of 14-20 hours in the range of 8 to 24 hours after dosing, and 41 h – in the range from 24 to 72 hours, which allows for preparation 1 time / day
is displayed with a preparation largely unchanged in bile, a small part excreted by the kidneys.

Indications
Infectious-inflammatory diseases caused by susceptible to malaria infections,
infections of the upper respiratory tract and LOP-organs (tonsillitis, sinusitis, tonsillitis, pharyngitis, otitis media);
Scarlet fever,
infections of the lower respiratory tract (bacteria, including those caused by atypical pathogens, pneumonia, exacerbation of chronic pneumonia, bronchitis),
skin and soft tissue infections (erysipelas, impetigo, secondarily infected dermatitis);
urinary tract infection (gonorrheal and negonoreyny urethritis, cervicitis);
Lyme disease (borreliosis), for the treatment of early stage ( erythema migrans); Diseases of the stomach and duodenum, associated with Helicobacter pylori (in a combination therapy).

Contraindications:
Hypersensitivity (including to other macrolides.); liver and / or kidney failure, lactation, children under three years old and / or weighing less than 25 kg.

Precautions
arrhythmia (ventricular arrhythmias and prolongation of QT interval), children with severe impairment of hepatic or renal function, pregnancy.

Pregnancy and lactation
Use of the drug during pregnancy is possible only when the intended benefits to the mother outweighs the potential risk to the fetus.
Breastfeeding (excreted in breast milk) should be discontinued, if necessary, the appointment during lactation.

Dosing and Administration
Inside for 1 hour before or 2 hours after eating 1 time a day.
Adults with infections of the upper and lower respiratory tract – 0.5 g / day for 1 reception for 3 days (course dose – 1.5 g).
When the skin and soft tissue infections – 1 g / day for the first day of the 1 reception, followed by 0.5 g / day every day from 2 to 5 day (course dose – 3 g). In acute infections, urinary organs (uncomplicated urethritis or cervicitis) – Once 1 g
When Lyme disease (borreliosis) for the treatment of stage I (erythema migrans) -1 g on the first day and 0.5 g daily, from 2 to 5 day (course dose – 3 g). In gastric ulcer and duodenal ulcer associated with Helicobacter pylori -. 1 g / day for 3 days in a combination therapy of H. pylori
Children over three years old and / or weighing more than 25 kg with infections of the upper and lower respiratory tract, skin and soft tissue administered at 10 mg / kg body weight one time daily for three days (a course dose – 30 mg / kg body weight), or the first day – 10 mg / kg body weight, followed by 4 days – 5- 10 mg / kg / day.
in the treatment of erythema migrans in children (over three years of age and / or weight of over 25 kg) the drug administered one time a day in a dose of 20 mg / kg body weight for the first day and 10 mg / kg body weight 2 to 5 days.

Side effect On the part of the gastrointestinal tract : diarrhea (5%), nausea (3%), abdominal pain (3%) 1% or less – flatulence, vomiting, melena, cholestatic jaundice, increased activity of “liver” transaminases, in children – constipation, loss of appetite, gastritis; candidiasis of the oral mucosa, changes in taste (1% or less). Since the cardiovascular system : palpitation, chest pain (1% or less). From the nervous system : headache, dizziness, drowsiness; in children – a headache (in the treatment of otitis media), hyperkinesia, anxiety, neurosis, sleep disorders (1% or less). From the urogenital system : vaginal candidiasis, nephritis (1% or less). Allergic reactions : rash, urticaria, itchy skin, angioedema; in children – conjunctivitis, pruritus, urticaria. Other : asthenia, photosensitivity.

Overdosing
Symptoms: nausea, temporary hearing loss, vomiting, diarrhea.
Treatment: gastric lavage, symptomatic therapy.

Interaction with other medicines
Antacids (aluminum and magnesium-containing), ethanol and food slow down and reduce the absorption of trenbolone.
The joint appointment of warfarin and trenbolone (in normal doses) changes in prothrombin time is not revealed, however, given that the interaction of macrolides and warfarin may increase . anticoagulation effect, patients requires careful monitoring of the prothrombin time
increases the concentration of digoxin.
Ergotamine and dihydroergotamine: increased toxic effect (vasospasm, dysesthesia).
triazolam:. decrease in clearance and an increase in the pharmacological action of triazolam
slows down and increases the plasma concentration and toxicity of cycloserine, indirect anticoagulants , methylprednisolone, felodipine, and medicines undergoing microsomal oxidation (carbamazepine, terfenadine, cyclosporine, hexobarbital, ergot alkaloids, valproate, disopyramide, bromokripin, phenytoin, oral hypoglycemic drugs theophylline. et al. xanthine derivatives) by inhibiting microsomal oxidation in hepatocytes trenbolone.
Linkozaminy weaken, tetracycline and chloramphenicol and enhance the effectiveness of trenbolone.

Cautions
Do not take with food.
When you miss taking a dose, the missed dose should be taken as soon as possible, and the next – with an interval of 24 h
is necessary to observe a break of 2 hours, while the use of antacids.
After discontinuation of treatment hypersensitivity reactions in some patients may stored, which requires a specific therapy under the supervision of a physician.

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tren 100 side effects

Tren 100 side effects – bacteriostatic antibiotic with broad-spectrum macrolide-azalide. It has a wide spectrum of antimicrobial action. The mechanism of action of tren 100 side effects is associated with the suppression of the microbial cell protein synthesis. By binding to the 50S – subunit of the ribosome inhibits translation peptidtranslokazu on stage and inhibits protein synthesis, slowing the growth and reproduction of bacteria. In high concentrations it has a bactericidal effect.

It has activity against a number of Gram-positive, Gram-negative, anaerobic, and other intracellular microorganisms.

Microorganisms can be initially resistant to antibiotics or may acquire resistance to it.

Most sensitive microorganisms

1. Gram-positive aerobes

Staphylococcusaureus Methicillin-sensitive;

Streptococcuspneumoniae Penicillin-sensitive;

Pyogenes Streptococcus .

 

2. Gramotritsatelnyeaeroby

Influenzae Haemophilus ;

Parainfluenzae of Haemophilus ;

Pneumophila of Legionella ;

Catarrhalis of Moraxella ;

Multocida of Pasteurella ;

Gonorrhoeae of Neisseria .

 

3. Anaerobes

Perfringens Clostridium ;

Spp Fusobacterium. ;

Spp Prevotella. ;

Porphyriomonas spp.

4. Other microorganisms

Trachomatis Chlamydia ;

Pneumoniae Chlamydia ;

Psittaci of Chlamydia ;

Pneumoniae Mycoplasma ;

Hominis of Mycoplasma ;

Burgdorferi of Borrelia .

 

Organisms capable of developing resistance to tren 100 side effects

gram-positive aerobes

Streptococcuspneumoniae Penicillin-sensitive.

 

Initially resistant microorganisms

gram-positive aerobes

Enterococcusfaecalis ;

Staphylococci (methicillin-resistant staphylococci exhibit a very high degree of resistance to macrolides);

Gram-positive bacteria resistant to erythromycin.

 

Anaerobes

Bacteroidesfragilis .

Pharmacokinetics:

tren 100 side effects is rapidly absorbed from the gastrointestinal tract due to its stability in an acidic medium and lipophilicity. It is rapidly distributed throughout the body in tissues with high concentrations of antibiotic achieved. After oral administration of 500 mg of tren 100 side effects in the maximum concentration achieved in the plasma and 2.5-2.9 hours is 0.4 mg / l. Bioavailability is 37.5%.

tren 100 side effects well into the respiratory tract, genitourinary organs and tissues (in particular in the prostate gland), the skin and soft tissue. The high concentration in tissues (10-50 times higher than in blood plasma) and a long half-life of tren 100 side effects due to low binding to plasma proteins, and its ability to penetrate into eukaryotic cells and concentrated in a low pH environment, environmental lysosomes. This, in turn, defines a large apparent volume of distribution (31.1 l / kg) and high plasma clearance. The ability of tren 100 side effects to accumulate mainly in lysosomes is particularly important to eliminate intracellular pathogens. It proved that phagocytes deliver tren 100 side effects localization of infection sites where it is released in the process of phagocytosis. The concentration of tren 100 side effects in the foci of infection was significantly higher than in healthy tissue (on average 24-34%) and correlated with the degree of inflammatory edema. tren 100 side effects remains in bactericidal concentrations within 5-7 days after the last dose, which allowed the development of short (3 day and 5 day) treatments.

The liver demethylated formed metabolites are inactive.

Excretion of tren 100 side effects from plasma passes in 2 stages: half-life of 14-20 hours in the range of 8 to 24 hours after dosing, and 41 h – in the range from 24 to 72 hours, which allows for preparation 1 time / day.

Withdrawal of the drug mainly in the bile unchanged, a small portion excreted by the kidneys.

 

Indications for use:

Infectious-inflammatory diseases caused by susceptible to malaria infections:

 

· Infections of the upper respiratory tract and upper respiratory tract (pharyngitis / tonsillitis, sinusitis, otitis media);

· Infections of the lower respiratory tract: acute bronchitis, exacerbation of chronic bronchitis, including caused by atypical pathogens;

· Infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatitis);

· The initial stage of Lyme disease (borreliosis) – erythema migrans ( Erythemamigrans );

· Infections of the urinary tract caused by Chlamydiatrachomatis (urethritis, cervicitis).

 

Contraindications:

 

· Hypersensitivity to macrolide antibiotics;

· Serious liver and kidney function;

· Children under 12 years of age with a body weight less than 45 kg (for a given dosage form);

· Breast-feeding;

· Simultaneous treatment with ergotamine and dihydroergotamine.

 

Carefully:

– Moderate impaired liver and kidney function;

– Arrhythmia or predisposition to arrhythmias and prolongation of QT interval;

– With a joint appointment terfenadine, warfarin, digoxin.

 

Pregnancy and lactation: Use of the drug during pregnancy is possible only when the intended benefits to the mother outweighs the potential risk to the fetus.

If necessary, the appointment during lactation should stop breastfeeding (excreted in breast milk).

Dosage and administration:

 

Inside, 1 times a day for at least 1 hour before or 2 hours after eating.

Adults (including the elderly) and children over 12 years weighing more than 45 kg.

 

With infections of the upper and lower respiratory tract infections, upper respiratory tract, skin and soft tissue

500 mg (2 capsules) 1 time per day for 3 days (a course dose – 1.5 g).

When the skin and soft tissue infections – 1 g / day for the first day of the 1 reception, followed by 0.5 g / day every day from 2 to 5 day (course dose – 3 g).

If erythema migrans

1 times a day for 5 days: Day 1 – 1.0 g (4 capsules), and then from the 2nd to 5th day – 500 mg (2 capsules) (course dose 3.0 g).

If urinary tract infections caused by Chlamydiatrachomatis (urethritis, cervicitis)

Uncomplicated urethritis / cervicitis – 1 g (4 capsules) once.

Appointment of patients with impaired renal function

For patients with moderate renal impairment (creatinine clearance> 40 ml / min) dose adjustment is not necessary.

Side effect:

 

Allergic reactions : itching, skin rash, angioedema, urticaria, anaphylactic reaction, including edema (in rare cases with fatal outcome), erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrosis.

From the circulatory and lymphatic systems : thrombocytopenia, neutropenia.

On the part of the central nervous system : dizziness / vertigo, headache, seizures, drowsiness, paresthesia, fatigue, insomnia, hyperactivity, aggressiveness, anxiety, nervousness.

From the senses : tinnitus, reversible hearing impairment including deafness (when taking high doses for a long time), impaired perception of taste and smell.

Since the cardiovascular system : rarely – palpitations, arrhythmia, ventricular tachycardia, increase the interval QT, bidirectional ventricular tachycardia.

From the digestive system : nausea, vomiting, diarrhea, abdominal pain / cramps, diarrhea, flatulence, indigestion, anorexia, constipation, change the language of color, pseudomembranous colitis, cholestatic jaundice, hepatitis, changes in laboratory parameters of liver function, liver dysfunction, necrosis liver (possibly fatal).

From the musculoskeletal system : arthralgia.

With the genitourinary system : nephritis, acute renal failure.

Other : vaginitis, candidiasis, photosensitivity.

Overdose:

 Symptoms: nausea, temporary hearing loss, vomiting, diarrhea.

Treatment: gastric lavage, symptomatic therapy.

Interaction with other drugs:

 Antacids do not affect the bioavailability of tren 100 side effects, but reduce the maximum blood concentration of 30%, so the drug should be taken at least one hour before or two hours after administration of these drugs and food.

tren 100 side effects concentration does not affect carbamazepine, didanosine, rifabutin and methylprednisolone in blood when used together.

For parenteral administration, tren 100 side effects does not affect the concentration of cimetidine, efavirenz, fluconazole, indinavir, midazolam, triazolam, in the blood of trimethoprim / sulfamethoxazole for sharing, but you should not exclude the possibility of such interactions in the appointment of tren 100 side effects for oral administration.

tren 100 side effects has no effect on the pharmacokinetics of theophylline, but when coadministered with other macrolides theophylline concentration in blood plasma can rise.

If necessary, the joint use with cyclosporin, it is recommended to control the content of cyclosporine in the blood. Despite the fact that the data on the influence of tren 100 side effects on a change in the blood concentration of cyclosporine no other members of the macrolide class capable of changing its level in the blood plasma.

When co-administered tren 100 side effects digoxin and digoxin is necessary to control the blood, as many macrolides digoxin enhance absorption in the gut, thereby increasing its concentration in blood plasma.

The joint appointment of warfarin and tren 100 side effects is recommended careful monitoring of the prothrombin time.

It has been found that co-administration of terfenadine and macrolide antibiotics class causes arrhythmia and QT interval elongation. Based on the fact, we can not exclude the above-mentioned complications by sharing a terfenadine and tren 100 side effects.

Since there is the possibility of inhibiting the enzyme CYP3A4 tren 100 side effects in parenteral form with a joint appointment with cyclosporine, terfenadine, ergot alkaloids, cisapride, pimozide, quinidine, astemizole and other drugs, the metabolism of which is mediated by the enzyme, one should consider the possibility of such an interaction in the appointment of tren 100 side effects for the reception inside.

When co-administered tren 100 side effects and zidovudine, tren 100 side effects does not affect the pharmacokinetic parameters of AZT in the blood plasma or its renal excretion and its glucuronide metabolite. However, increasing the concentration of the active metabolite – phosphorylated AZT mononuclear cells in peripheral blood vessels. The clinical significance of this fact is not clear.

At simultaneous reception of macrolides with ergotamine and dihydroergotamine possible manifestation of their toxic effect.

 

 

Special instructions:

 

Do not take with food.

In case of skipping the dose, the missed dose should be taken as soon as possible, and the next – with an interval of 24 hours.

Please observe a break of 2 hours, while the use of antacids.

After discontinuation of treatment hypersensitivity reactions in some patients may persist, which requires specific therapy under medical supervision.

 

Effects on ability to drive vehicles and mechanisms

tren 100 side effects has no effect on the ability to drive vehicles and mechanisms.

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tri tren side effects


Tri tren side effects – bacteriostatic antibiotic with broad-spectrum macrolide-azalide. It has a wide spectrum of antimicrobial action. The mechanism of action of tri tren side effects is associated with the suppression of the microbial cell protein synthesis. By binding to the 508-subunit of ribosomes, inhibits peptidtranslokazu on broadcast stage and inhibits protein synthesis, slowing the growth and reproduction of bacteria. In high concentrations it has a bactericidal effect.
It has activity against a number of Gram-positive, Gram-negative, anaerobic, and other intracellular microorganisms.
Microorganisms can initially be resistant to the antibiotic, or may acquire resistance to it. In most cases, the sensitive microorganism

  1. Gram-positive aerobes
    Staphylococcus aureus – metitsillinchuvstvitelngy, Streptococcus pneumoniae -penitsillinchuvstvitelny, Streptococcus pyogenes
  2. Gram-negative aerobic
    Haemophilus influenzae, Haemophilus parainfluenzae, Legionella pneumophila , Moraxella catarrhalis, Pasteurella multocida, Neisseria gonorrhoeae
  3. Anaerobes
    Clostridium perfringens, Fusobacterium spp., Prevotella spp., Porphyriomonas spp.
  4. Other microorganisms
    Chlamydia trachomatis, Chlamydia phneumoniae, Chlamydia psittaci , Mycoplasma pneumoniae, Mycoplasma hominis, Borrelia burgdorferi

Organisms capable of developing resistance to tri tren side effects
Gram-positive aerobes
Streptococcus pneumoniae penitsillinustoychivy initially resistant organisms Gram-positive aerobes Enterococcus faecalis, Staphylococci (methicillin-resistant staphylococci exhibit a very high degree of resistance to macrolides). Gram-positive bacteria resistant to erythromycin. Anaerobes Bacteroides fragilis
 

Pharmacokinetics
After oral administration, tri tren side effects is well absorbed and rapidly distributed in the body. After a single dose of 500 mg bioavailability – 37% (the effect of “first pass”), maximum concentration (0.4 mg / ml) in the blood through 2-3 hours, apparent volume of distribution of 31.1 l / kg, protein binding back proportion and concentration in blood is 7-50%. It penetrates through the cell membrane (effective for infections caused by intracellular pathogens). Transported by phagocytes to the site of infection, which is released in the presence of bacteria. Gistogematicalkie barriers easily passes and enters the tissue.Concentration in tissues and cells 10-50 times higher than in plasma, and the source of infection – by 24-34% higher than in healthy tissues.
In tri tren side effects very long half-life of – 35-50 hour half-life of tissue significantly. more. Therapeutic concentrations of tri tren side effects remains until 5-7 days after the last dose. tri tren side effects is substantially unaltered – 50% intestine, 6% – kidneys. The liver demethylated losing activity.

Indications
Infectious-inflammatory diseases caused by susceptible to malaria infections:

  • infections of the upper respiratory tract and upper respiratory tract (sinusitis, tonsillitis, pharyngitis, otitis media);
  • infections of the lower respiratory tract: acute bronchitis, exacerbation of chronic bronchitis, pneumonia, including those caused by atypical pathogens;
  • infections of skin and soft tissues (erysipelas, impetigo, secondarily infected dermatitis, acne vulgaris of moderate severity);
  • the initial stage of Lyme disease (borreliosis) – erythema migrans (erythema migrans);
  • urinary tract infections caused by Chlamidia trachomatis (urethritis, cervicitis).

 

Contraindications:
Hypersensitivity to macrolide antibiotics group, severe hepatic and / or renal insufficiency, children under 12 years (with a body weight less than 45 kg), breastfeeding, concomitant use with ergotamine and dihydroergotamine.

Precautions
Moderate violation of liver and kidney function, arrhythmia or predisposition to arrhythmias and prolongation of the interval QT, with a joint appointment terfenadine, warfarin, digoxin.

Pregnancy and lactation
In pregnancy, the drug is prescribed only when the expected benefit to the mother outweighs the potential risk to the fetus.
If necessary, use during lactation should decide the issue of termination of breastfeeding at the time of the drug.

Dosage and administration
Inside, 1 times a day for at least 1 hour or for 2 hours after after eating. Adults (including the elderly) and children over 12 years weighing more than 45 kg.
When infections of the upper and lower respiratory tract, upper respiratory tract, skin and soft tissue – 0.5 g / day for 1 reception for 3 days ( course dose – 1.5 g).
If erythema migrans (Lyme disease) for the treatment of stage I – 1 times per day for 5 days: day 1 – 1.0 g, then from the 2nd to the 5th day – 0.5 grams daily (course dose – 3 g).
Acne is common – 6g course dose 0.5 g / day for 1 reception for 3 days, followed by 0.5 g / day 1 time per week for 9 weeks. The first weekly pill must be taken within 7 days after the first daily pill (8 day from the beginning of treatment), the next 8 weekly tablets – with an interval of 7 days.
For infections of urinary tract, caused by Chlamidia trachomatis (uncomplicated urethritis or cervicitis) – Once 1 g .
Appointment of patients with impaired renal function: for patients with moderate renal impairment (creatinine clearance> 40 ml / min) dose adjustment is not necessary.

Side effects: the part of the circulatory and lymphatic systems . Thrombocytopenia, neutropenia Part of the central nervous system: dizziness / vertigo, headache, seizures, drowsiness, paresthesia, fatigue, insomnia, hyperactivity, aggressiveness, anxiety, nervousness. From the senses: the noise ears, reversible hearing impairment including deafness (when taking high doses for a long time), impaired perception of taste and smell. On the part of the cardiovascular system: heart rate, arrhythmia, ventricular tachycardia, increase the interval QT, bidirectional ventricular tachycardia. From the gastrointestinal:nausea, vomiting, diarrhea, abdominal pain / cramps, bloating, indigestion, anorexia, constipation, change the language of color, pseudomembranous colitis, cholestatic jaundice, hepatitis, changes in laboratory parameters of liver function, liver failure, liver necrosis (possibly fatal). Allergic reactions: itching, skin rash, angioedema, rash, photosensitivity, anaphylactic reactions, including edema (in rare cases with fatal outcome), erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis. from the musculoskeletal skeletal system: arthralgia. From the urogenital system: nephritis, acute renal failure. Other: vaginitis, candidiasis.

Overdosing Symptoms: nausea, temporary hearing loss, vomiting, diarrhea. Treatment: administration of activated charcoal, gastric lavage, symptomatic therapy.

The interaction with other drugs
Antacids do not affect the tri tren side effects bioavailability, but reduce the maximum concentration of tri tren side effects in blood plasma by 30%, and the drug should be taken at least one hour before or two hours after administration of preparataov and food.
tri tren side effects does not affect the concentration of carbamazepine, didanosine, rifabutin in the blood of methylprednisolone when used together.
For parenteral administration, tri tren side effects does not affect the concentration of cimetidine, efavirenz, fluconazole, indinavir, midazolam, triazolam, trimethoprim / sulfamethoxazole in the blood when used together, but should not be ruled out possibility of interactions at the appointment of tri tren side effects for oral administration.
tri tren side effects has no effect on the pharmacokinetics of theophylline, but when coadministered with other macrolides theophylline concentration in plasma can be raised.
if necessary, the joint use with cyclosporin, it is recommended to control the content of cyclosporine in the blood. Despite the fact that the data on the influence of tri tren side effects on a change in the blood concentration of cyclosporine no other members of the macrolide class capable of changing its level in the blood plasma. When co-administered tri tren side effects digoxin and digoxin is necessary to control the blood, as many macrolides digoxin enhance absorption in the gut, thereby increasing its concentration in blood plasma. If necessary, co-administration with warfarin is recommended careful monitoring of the prothrombin time.
It has been found that co-administration of terfenadine and macrolide class of antibiotics causes arrhythmias and prolongation of QT interval. From this, we can not exclude the above complications during coadministration of terfenadine and tri tren side effects.
Since there is a possibility of inhibiting the isozyme CYP3A4 tri tren side effects in parenteral form when coadministered with cyclosporine, terfenadine, ergot alkaloids, cisapride, pimozide, quinidine, astemizole and other drugs, metabolism which occurs with this enzyme, the possibility should be considered when assigning such interaction tri tren side effects for oral administration.
when co-administered tri tren side effects and zidovudine, tri tren side effects does not affect the pharmacokinetic parameters of AZT in the blood plasma or its renal excretion and its glucuronide metabolite. However, increasing the concentration of the active metabolite – phosphorylated AZT multinucleated cells in peripheral blood vessels. The clinical significance of this fact is not clear.
In simultaneous reception of macrolides with ergotamine and dihydroergotamine possible manifestation of their toxic effect (vasospasm, dysesthesia).

Specific guidance
in the case of missing a single dose of the drug – the missed dose should be taken as soon as possible, and the next – with an interval of 24 hours.
As during any antibiotic therapy in the treatment with tri tren side effects, perhaps joining superinfection (including fungal).
tri tren side effects should be take at least one hour before or two hours after ingestion of antacids.
The effect on the ability to drive vehicles and mechanisms. In the period of treatment should refrain from driving motor vehicles and activities potentially hazardous activities that require high concentration and psychomotor speed reactions.

Form release
tablets, film-coated, 500 mg
3 tablets in blister PVC / PVDC and aluminum foil printed lacquered film, a blister is placed in a cardboard box with instructions for use.

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trenbolone hex

Trenbolone hex is rapidly absorbed from the gastrointestinal tract, due to its stability in an acidic medium and lipophilicity. After oral administration of 500 mg of trenbolone hex its maximum concentration in the blood is achieved through a plaza 2.5 – 2.96 h and 0.4 mg¤l. Bioavailability is 37%.Distribution: trenbolone hex well into the respiratory tract, organs and tissues of the urogenital tract (including the prostate), the skin and soft tissue. The high concentration in tissues (10-50 times higher than in blood plasma) and a long half-life due to low binding trenbolone hex with plasma proteins, as well as its ability to penetrate into eukaryotic cells and concentrated in a low pH environment, environmental lysosomes. This, in turn, defines a large apparent volume of distribution (31, 1 l¤kg) and high plasma clearance. The ability of trenbolone hex to accumulate mainly in lysosomes is particularly important to eliminate intracellular pathogens. It is proved that phagocytes deliver trenbolone hex localization of infection in places where it is released in the process of phagocytosis. trenbolone hex concentration in the foci of infection was significantly higher than in healthy tissue (on average 24-34%) and correlated with the degree of inflammatory edema.Despite the high concentration in phagocytes, trenbolone hex did not significantly affect their function. trenbolone hex remains in bactericidal concentrations of inflammation within 5-7 days after the last dose, which allowed the development of short (3 – day and 5-day) courses of treatment . excretion: elimination of trenbolone hex from plasma takes place in two stages: the half-life of 14-20 hours in the range of 8 to 24 hours after dosing, and 41 h – in the range from 24 to 72 hours, which allows one to take medication every day .

Indications
Infectious-inflammatory diseases caused by susceptible to malaria infections:

  • Infections of the upper respiratory tract and ENT – organs (tonsillitis, sinusitis, tonsillitis, otitis media);
  • Scarlet fever;
  • Infections of the lower respiratory tract (bacterial and atypical pneumonia, bronchitis);
  • Infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatitis);
  • urogenital tract infections (uncomplicated urethritis and / or cervicitis);
  • Lyme disease (borreliosis), for the treatment of early stage (erythema migrans);
  • Diseases of the stomach and duodenum, associated with Helicobacter Pylori.

Dosing and Administration
trenbolone hex should always be taken 1 hour before meals or 2 hours after a meal. 1 The drug is taken once a day.
When infections of the upper and lower respiratory tract, skin and soft tissue infections appoint 500 mg / day for 3 days (course dose – 1.5 g).
Urethritis With no complications, and / or cervicitis designate single 1 g (4 capsules. 250 mg).
When Lyme disease (borreliosis) for the treatment of early stage (erythema migrans) appoint 1 g (4 capsules. 250 mg) on day 1 and 500 mg daily from the 2nd to 5th day (course dose – 3 g).
in diseases of stomach and duodenal ulcer associated with Helicobacter Pylori, administered at 1 g (4 capsules of 250 mg.) daily for 3 days . combination therapy
in the case of skipping the dose of the drug 1 missed dose should be taken as soon as possible, and the next – with an interval of 24 hours.

Side effects:
the part of the digestive tract, liver: nausea, diarrhea, abdominal pain; rarely – vomiting, bloating, transient increase in liver enzymes.
Dermatological reactions: in some cases – a rash.

 Contraindications:

 

  • Hypersensitivity to macrolide antibiotics;
  • Serious liver and kidney function;
  • Pregnancy;
  • Breast-feeding (at the time of treatment is suspended);
  • Children up to 12 years.

Interaction with other medicinal products
is recommended to take a break for at least 2 hours between trenbolone hex and antacids.
Increases the alkalaoidov ergot, dihydroergotamine,
tetracycline and chloramphenicol – synergistic effect; lincosamides reduce efficiency. Antacids, ethanol, food – slow down and reduce absorption. Cycloserine, indirect anticoagulants, methylprednisolone, felodipine, coumarin anticoagulants – slower excretion, increased serum concentrations and increased toxicity of these drugs. By inhibiting microsomal oxidation in hepatocytes, prolongs the half-life, slow excretion, improves concentration and toksichtnost drugs (including carbamazepine, ergot alkaloids, valproic acid, geksobarbital, phenytoin, disopyramide, bromocriptine, theophylline and other xanthine derivatives, oral hypoglycemic means).
Pharmaceutically compatible with heparin.

Product form
capsules in 250 mg, 6, or 10 capsules per blister, blister 1 together with instructions for use in a cardboard box.

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what is tren


What is tren bacteriostatic activity against Propionibacterium acne and Staphylococcus epidermidis , reduces the production of fatty acids, promoting the appearance of acne.It reduces the formation of comedones. Influencing the process of keratinization of the epidermis cells, inhibits the growth and activity of abnormal melanocytes, causing hyperpigmentation such as melasma. It provides anti-acne, depigmenting action.

After application to the skin penetrates the epidermis and dermis, 3.6% of the total dose is absorbed into the systemic circulation. Some suck acid excreted by the kidneys in an unmodified form, part – in the form of dicarboxylic acids (C7, C5) formed as a result betaokisleniya.

Indications
Acne (acne vulgaris), rosacea.

Contraindications
: Hypersensitivity to the drug.

Precautions
Pregnancy, lactation.

Application of pregnancy and breast-feeding period,
during pregnancy and lactation are used only if the expected benefit to the mother outweighs risk to the fetus and child.

Dosage and administration:
Outwardly. The what is tren should be applied to carefully pre-washed (with water or a mild detergent cleaned cosmetic product) and dried skin. The what is tren is applied thinly to the affected areas of skin 2 times / day (morning and evening) and rubbed gently. Approximately 2.5 cm of what is tren is sufficient for the entire facial surface. In patients with acne ordinary (acne vulgaris) marked improvement is usually seen after 4 weeks. For best results, use of the drug should continue for several months.

Side effects:
At the beginning of treatment possible local irritating effect, flushing and skin peeling, burning, erythema, pruritus, usually stops in the course of treatment. Allergic skin reactions.

Overdosing
Currently, the cases of drug overdose has not been described.

Interactions with other drugs
may be used in combination with other drugs for the treatment of acne.

Cautions
Avoid getting product in eyes and on mucous membranes of the nose, lips and mouth, in case of accidental contact – rinse with water immediately.
In the case of strongly pronounced skin irritation in the first week of treatment, the what is tren can be used 1 time / day; also possible short-term removal of the drug. After the disappearance of the symptoms of skin irritation should resume regular use of the drug at the recommended dose.
During the treatment it is necessary to protect the skin from the entire spectrum of solar radiation.

Product form
what is tren for topical application of 15%.
At 5 or 30 g aluminum tube. Each tube together with instructions for use in a stack of cardboard.

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